Parental origin, nondisjunction, and recombination of the extra chromosome 21 in Down syndrome: a study in a sample of the Colombian population Nelson Javier Ramírez, Helen Marcela Belalcázar, Juan José Yunis … [et.al]

Proyecto de grado presentado a Colombia. Universidad Nacional, Facultad de Medicina, como requisito para optar al título de Doctor en Medicina y Cirugía, asesorado por Gonzalo Esguerra Gómez, línea de investigación Medicina

Introduction. Free trisomy 21 is responsible for 95 per cent of Down syndrome cases. Advanced maternal age and susceptible recombination patterns are recognized risk factors associated to Down syndrome. Maternal origin of trisomy occurs in approximately 9